This one is very rare form of cancer also known as cholangiocarcinoma. It can originate anywhere in the bile ducts, particularly in those outside of the liver. Bile ducts are small tubes that connect the liver and small intestine. They allow fluid called bile to flow from the liver, through the pancreas, to the gut, where it helps with digestion. Cancer can affect any part of these ducts. Being older (65 or above) or having primary sclerosing cholangitis increases the risk of developing this cancer.

Cancer of the gallbladder is also rare. This cancer begins in gallbladder which is a part of digestive system. The cancer starts in gland cells in the gallbladder lining. These gland cells normally produce mucus (thick fluid). Nearly everyone with gallbladder cancer has gallstones. Many people live only a few months after this cancer develops.